BCAS2 Antikörper (C-Term)

Produktnummer ABIN6991284

Produktdetails anti-BCAS2 Antikörper

Target: BCAS2 (Breast Carcinoma Amplified Sequence 2 (BCAS2))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BCAS2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: BCAS2 Antibody is affinity chromatography purified via peptide column.

Immunogen: BCAS2 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human BCAS2. The immunogen is located within the last 50 amino acids of BCAS2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: BCAS2 antibody can be used for detection of BCAS2 by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: BCAS2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: BCAS2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu BCAS2

Target: BCAS2 (Breast Carcinoma Amplified Sequence 2 (BCAS2))

Andere Bezeichnung: BCAS2 (BCAS2 Produkte)

Synonyme: DAM1 antikoerper, SPF27 antikoerper, Snt309 antikoerper, 6430539P16Rik antikoerper, AI132645 antikoerper, C76366 antikoerper, C80030 antikoerper, BCAS2 antikoerper, cb302 antikoerper, zgc:101730 antikoerper, BCAS2, pre-mRNA processing factor antikoerper, breast carcinoma amplified sequence 2 antikoerper, breast carcinoma amplified sequence 2 L homeolog antikoerper, BCAS2 antikoerper, Bcas2 antikoerper, bcas2 antikoerper, bcas2.L antikoerper, CpipJ_CPIJ003889 antikoerper

Hintergrund: BCAS2 Antibody: BCAS2 was identified through differential display analysis as an mRNA species that was overexpressed in MCF7 and BT-20 breast cancer cell lines. The chromosomal region containing this gene, 1p13.3021, is amplified in these cells lines. BCAS2 is a transcriptional cofactor that enhances estrogen receptor-mediated gene expression, and directly interacts with the tumor suppressor p53 to reduce p53 transcriptional activity by reducing p53 protein level in the absence of DNA damage. Deprivation of BCAS2 through RNA inhibition induces apoptosis in p53-wild type cells, but causes G2-M arrest in p53-null or -mutant cells, this effect was reversed with the expression of ectopic BCAS2. BCAS2 may thus be potentially useful as a therapeutic target in the treatment of cancer.

Gen-ID: 10286

UniProt: O75934