RHBDD3 Antikörper (AA 170-220)

Produktnummer ABIN6991242

Der Kaninchen Polyklonal anti-RHBDD3 Antikörper (ABIN6991242) detektiert spezifisch RHBDD3 in WB, ELISA und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für RHBDD3 Antikörper (AA 170-220) (ABIN6991242)

Target: RHBDD3 (Rhomboid Domain Containing 3 (RHBDD3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RHBDD3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Produktdetails anti-RHBDD3 Antikörper

Bindungsspezifität: AA 170-220

Aufreinigung: RHBDD3 Antibody is affinity chromatography purified via peptide column.

Immunogen: RHBDD3 antibody was raised against a 13 amino acid synthetic peptide from near the center of human RHBDD3. The immunogen is located within amino acids 170 - 220 of RHBDD3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: RHBDD3 antibody can be used for detection of RHBDD3 by Western blot at 1 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: RHBDD3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: RHBDD3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu RHBDD3

Target: RHBDD3 (Rhomboid Domain Containing 3 (RHBDD3))

Andere Bezeichnung: RHBDD3

Hintergrund: RHBDD3 Antibody: The Rhomboid family of proteins is made up of several widely conserved polytopic membrane serine proteases that play roles in growth and development. RHBDD3 was initially identified as a novel pituitary tumor apoptosis gene (PTAG) whose expression was reduced in certain pituitary adenomas. Overexpression of RHBDD3 in AtT20 cells showed an increase in apoptotic activity and caspase activation in response to bromocriptine, and apoptosis-inducing dopamine D2 analog, suggesting that reactivation of RHBDD3 in tumors may be a therapeutically useful tool. Later experiments also showed that RHBDD3 expression is also reduced in several primary colorectal tumors, indicating that loss of RHBDD3 contributes to a blunted apoptotic response and probably predisposes cells towards malignant transformation.

Gen-ID: 25807

NCBI Accession: NP_036397

UniProt: Q9Y3P4