ZNF536 Antikörper (N-Term)

Produktnummer ABIN6991232

Der Kaninchen Polyklonal Anti-ZNF536-Antikörper wurde für WB, ELISA, IHC (p) und IF validiert. Er ist geeignet, ZNF536 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für ZNF536 Antikörper (N-Term) (ABIN6991232)

Target: ZNF536 (Zinc Finger Protein 536 (ZNF536))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZNF536 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Produktdetails anti-ZNF536 Antikörper

Bindungsspezifität: AA 30-80, N-Term

Aufreinigung: ZNF536 Antibody is affinity chromatography purified via peptide column.

Immunogen: ZNF536 antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human ZNF536. The immunogen is located within amino acids 30 - 80 of ZNF536.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ZNF536 antibody can be used for detection of ZNF536 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: ZNF536 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: ZNF536 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu ZNF536

Target: ZNF536 (Zinc Finger Protein 536 (ZNF536))

Andere Bezeichnung: ZNF536

Hintergrund: ZNF536 Antibody: ZNF536 is a recently identified zinc-finger protein that is expressed primarily in the developing nervous system and the cerebral cortex, hippocampus, and hypothalamus. ZNF536 possess ten zinc fingers and interacts with CtBP1, a corepressor for gene transcription. It is most closely related to transcriptional repressor ZNF219. Overexpression of ZNF536 in embryonic stem cells dramatically reduced the mRNA levels of neuronal marker genes such as Pax6, MAP2, and beta-tubulin III following retinoic acid (RA)-induced differentiation, while depletion of ZNF536 via RNAi resulted in elevated mRNA levels of these genes, indicating its role in inhibiting neuronal cell differentiation. Overexpression of RA receptor a rescues the inhibitory role of ZNF536, suggesting that ZNF536 might inhibit RA response element-mediated transcriptional activity.

Gen-ID: 9745

NCBI Accession: NP_055532

UniProt: O15090

Pathways: Retinoic Acid Receptor Signaling Pathway