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GOLPH3 Antikörper (N-Term)

GOLPH3 Reaktivität: Human, Maus, Ratte WB, ELISA, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6991206
  • Target Alle GOLPH3 Antikörper anzeigen
    GOLPH3 (Golgi phosphoprotein 3 (Coat-Protein) (GOLPH3))
    Bindungsspezifität
    • 15
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 44
    • 13
    • 7
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 39
    • 4
    • 1
    Kaninchen
    Klonalität
    • 42
    • 2
    Polyklonal
    Konjugat
    • 26
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser GOLPH3 Antikörper ist unkonjugiert
    Applikation
    • 39
    • 13
    • 13
    • 12
    • 10
    • 7
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    Western Blotting (WB), ELISA, Immunofluorescence (IF)
    Aufreinigung
    GOLPH3 Antibody is affinity chromatography purified via peptide column.
    Immunogen
    GOLPH3 antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus of human GOLPH3. The immunogen is located within the first 50 amino acids of GOLPH3.
    Isotyp
    IgG
    Top Product
    Discover our top product GOLPH3 Primärantikörper
  • Applikationshinweise
    GOLPH3 antibody can be used for detection of GOLPH3 by Western blot at 0.5 - 1 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

    Antibody validated: Western Blot in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    GOLPH3 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,4 °C
    Informationen zur Lagerung
    GOLPH3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    GOLPH3 (Golgi phosphoprotein 3 (Coat-Protein) (GOLPH3))
    Andere Bezeichnung
    GOLPH3 (GOLPH3 Produkte)
    Synonyme
    wu:fj66a10 antikoerper, zgc:101573 antikoerper, zgc:110223 antikoerper, 4733401N08Rik antikoerper, 5730410D03Rik antikoerper, AW413496 antikoerper, GOPP1 antikoerper, GPP34 antikoerper, MIDAS antikoerper, Gmx33 antikoerper, golgi phosphoprotein 3 antikoerper, golph3 antikoerper, CpipJ_CPIJ009278 antikoerper, Golph3 antikoerper, GOLPH3 antikoerper
    Hintergrund
    GOLPH3 Antibody: GOLPH3 was initially identified as a peripheral membrane protein localized to the trans-Golgi network, but others reported it to be primarily a mitochondrial protein that regulated the mitochondrial mass through the regulation of the mitochondria-specific phospholipid cardiolipin. GOLPH3 has since been implicated in the target of rapamycin (TOR) signalling pathway. Its overexpression in transfected cells led to and increase in anchorage-independent growth and cell proliferation in vitro. Furthermore, GOLPH3-transfected cells enhanced S6 Kinase activity in response to growth factor stimulation by EGF. Simultaneously, AKT phosphorylation increased in these cells, while these events were abrogated in GOLPH3 siRNA treated cells compared to control cells, indicating the GOLPH3 can enhance signalling through TOR-associated complexes. These results suggest that GOLPH3 is a bona fide oncogene and may be a useful target for therapeutic strategies.
    Gen-ID
    64083
    UniProt
    Q9H4A6
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