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RWDD3 Antikörper (N-Term)

RWDD3 Reaktivität: Human, Maus, Ratte WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6991194
  • Target Alle RWDD3 Antikörper anzeigen
    RWDD3 (RWD Domain Containing 3 (RWDD3))
    Bindungsspezifität
    • 12
    • 9
    • 2
    • 1
    • 1
    N-Term
    Reaktivität
    • 22
    • 7
    • 6
    • 2
    • 1
    Human, Maus, Ratte
    Wirt
    • 21
    • 1
    Kaninchen
    Klonalität
    • 22
    Polyklonal
    Konjugat
    • 12
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser RWDD3 Antikörper ist unkonjugiert
    Applikation
    • 21
    • 16
    • 15
    • 11
    • 2
    • 2
    Western Blotting (WB), ELISA
    Aufreinigung
    RWDD3 Antibody is affinity chromatography purified via peptide column.
    Immunogen
    RWDD3 antibody was raised against a 17 amino acid synthetic peptide from near the amino terminus of human RWDD3. The immunogen is located within the first 50 amino acids of RWDD3.
    Isotyp
    IgG
    Top Product
    Discover our top product RWDD3 Primärantikörper
  • Applikationshinweise
    RWDD3 antibody can be used for detection of RWDD3 by Western blot at 0.5 μ,g/mL.

    Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    RWDD3 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,4 °C
    Informationen zur Lagerung
    RWDD3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    RWDD3 (RWD Domain Containing 3 (RWDD3))
    Andere Bezeichnung
    RWDD3 (RWDD3 Produkte)
    Synonyme
    DKFZp469N1913 antikoerper, RSUME antikoerper, 2510027J23Rik antikoerper, 3110037C01Rik antikoerper, AI035684 antikoerper, AI662458 antikoerper, X2CR1 antikoerper, X2cr1 antikoerper, zgc:73229 antikoerper, RWD domain containing 3 antikoerper, RWDD3 antikoerper, rwdd3 antikoerper, Rwdd3 antikoerper
    Hintergrund
    RWDD3 Antibody: RWDD3 (RSUME), a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune-inflammatory signals. RWDD3 increases Iκ,Beta sumoylation and stability. In addition, RWDD3 inhibits TNF-α,-induced kappaB-LUC (Luciferase) reporter activity, showing the functional consequence of Iκ,Beta increased stability. RSUME-enhanced sumoylation of Iκ,Beta leads to the inhibition of NF-κ,Beta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways. Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization. Both BMP-4 and RWDD3 may be interesting targets for inhibiting steps involved in pituitary tumorigenesis.
    Gen-ID
    25950
    NCBI Accession
    NP_056300
    UniProt
    Q9Y3V2
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