RWDD3 Antikörper (N-Term)

Produktnummer ABIN6991194

Dieses Anti-RWDD3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von RWDD3 in WB und ELISA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für RWDD3 Antikörper (N-Term) (ABIN6991194)

Target: RWDD3 (RWD Domain Containing 3 (RWDD3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RWDD3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-RWDD3 Antikörper

Bindungsspezifität: N-Term

Aufreinigung: RWDD3 Antibody is affinity chromatography purified via peptide column.

Immunogen: RWDD3 antibody was raised against a 17 amino acid synthetic peptide from near the amino terminus of human RWDD3. The immunogen is located within the first 50 amino acids of RWDD3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: RWDD3 antibody can be used for detection of RWDD3 by Western blot at 0.5 μ,g/mL.

Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: RWDD3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: RWDD3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu RWDD3

Target: RWDD3 (RWD Domain Containing 3 (RWDD3))

Andere Bezeichnung: RWDD3

Hintergrund: RWDD3 Antibody: RWDD3 (RSUME), a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune-inflammatory signals. RWDD3 increases Iκ,Beta sumoylation and stability. In addition, RWDD3 inhibits TNF-α,-induced kappaB-LUC (Luciferase) reporter activity, showing the functional consequence of Iκ,Beta increased stability. RSUME-enhanced sumoylation of Iκ,Beta leads to the inhibition of NF-κ,Beta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways. Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization. Both BMP-4 and RWDD3 may be interesting targets for inhibiting steps involved in pituitary tumorigenesis.

Gen-ID: 25950

NCBI Accession: NP_056300

UniProt: Q9Y3V2