TBKBP1 Antikörper (C-Term)

Produktnummer ABIN6991189

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch TBKBP1 in WB, ELISA, IF und IHC (p). Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für TBKBP1 Antikörper (C-Term) (ABIN6991189)

Target: TBKBP1 (TBK1 Binding Protein 1 (TBKBP1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TBKBP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-TBKBP1 Antikörper

Bindungsspezifität: AA 500-550, C-Term

Aufreinigung: Prosapip2 Antibody is affinity chromatography purified via peptide column.

Immunogen: Prosapip2 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human Prosapip2. The immunogen is located within amino acids 500 - 550 of Prosapip2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Prosapip2 antibody can be used for detection of Prosapip2 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in rat samples, Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Prosapip2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: Prosapip2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu TBKBP1

Target: TBKBP1 (TBK1 Binding Protein 1 (TBKBP1))

Andere Bezeichnung: Prosapip2

Hintergrund: Prosapip2 Antibody: Prosapip2 (TBKBP1) is essential for signal transduction during viral infection thus plays a major role in the TNF/NF-κ,B pathway. It is an adaptor protein that constitutively binds TBK1 (TANK-binding kinase) and IKBKE and may play a role in antiviral innate immunity. Prosapip2 is a 615 amino acid adaptor protein belonging to the fibrillar collagen family, consisting of trimers of identical alpha 1 chains which are linked to each other by interchain disulfide bonds. It has a ubiquitous expression with highest levels in ovary, followed by the neuronal system. Prosapip2 binds to TBK1 and helps in the activation of IRF3 which controls the expression of antiviral genes during infection. Recent studies show that Prosapip2 is an interaction partner of ProSAP2/Shank3 and actin, suggesting a role as a linker molecule between postsynaptic density and the cytoskeleton.

Gen-ID: 9755

NCBI Accession: NP_055541

UniProt: A7MCY6

Pathways: SARS-CoV-2 Protein Interaktom