FAM120A Antikörper (AA 610-660)

Produktnummer ABIN6991172

Der Kaninchen Polyklonal Anti-FAM120A-Antikörper wurde für WB, ELISA, IF und IHC (p) validiert. Er ist geeignet, FAM120A in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für FAM120A Antikörper (AA 610-660) (ABIN6991172)

Target: FAM120A (Family with Sequence Similarity 120A (FAM120A))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FAM120A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-FAM120A Antikörper

Bindungsspezifität: AA 610-660

Spezifität: This antibody will not cross-reacti with FAM120B / PGCC1.

Aufreinigung: FAM120A Antibody is affinity chromatography purified via peptide column.

Immunogen: FAM120A antibody was raised against an 18 amino acid synthetic peptide from near the center of human FAM120A. The immunogen is located within amino acids 610 - 660 of FAM120A.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FAM120A antibody can be used for detection of FAM120A by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: FAM120A Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: FAM120A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu FAM120A

Target: FAM120A (Family with Sequence Similarity 120A (FAM120A))

Andere Bezeichnung: FAM120A

Hintergrund: FAM120A Antibody: FAM120A (C9orf10) is a member of the constitutive coactivator of PPAR gamma family and the gene was mapped to chromosome 9q22.31. FAM120A was recently detected within the Pur-alpha-containing mRNA-protein complex in the brain. As a novel RNA-binding protein, FAM120A is a critical component of the oxidative stress-induced survival signaling. It may participate in mRNA transport in the cytoplasm. FAM120A activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. FAM120A protects cells from apoptosis through activation of SRKs in response to oxidative stress. Blocking of the survival signaling mediated by FAM120A, which sensitizes the cancer cells to stress-induced apoptosis, may be a novel therapeutic approach for gastric scirrhous carcinoma cells.

Gen-ID: 23196

NCBI Accession: NP_055427

UniProt: Q9NZB2