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SYPL2 Antikörper (C-Term)

SYPL2 Reaktivität: Human, Maus, Ratte ELISA, WB, IHC (p), IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6991151
  • Target Alle SYPL2 Antikörper anzeigen
    SYPL2 (Synaptophysin-Like 2 (SYPL2))
    Bindungsspezifität
    C-Term
    Reaktivität
    Human, Maus, Ratte
    Wirt
    Kaninchen
    Klonalität
    Polyklonal
    Applikation
    ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
    Spezifität
    At least two isoforms of SYPL2 are known to exist. SYPL2 antibody will not cross-react with SYPL1.
    Aufreinigung
    SYPL2 Antibody is affinity chromatography purified via peptide column.
    Immunogen
    SYPL2 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human SYPL. The immunogen is located within the last 50 amino acids of SYPL2.
    Isotyp
    IgG
  • Applikationshinweise
    SYPL2 antibody can be used for detection of SYPL2 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

    Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    SYPL2 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,4 °C
    Informationen zur Lagerung
    SYPL2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    SYPL2 (Synaptophysin-Like 2 (SYPL2))
    Andere Bezeichnung
    SYPL2 (SYPL2 Produkte)
    Hintergrund
    SYPL2 Antibody: SYPL2, also known as Mitsugumin 29, was initially identified as a transmembrane protein from the triad junction in skeletal muscle that had significant homology with members of the synaptophysin family. SYPL2 is thought to participate in the excitation-contraction coupling process of skeletal muscle as SYPL2-null mice showed reduced muscle contractile force and altered triad junction structure and increased susceptibility to fatigue of the skeletal muscle. SYPL2 plays a critical role in muscle Ca2+ signaling by regulating the process of store-operated Ca2+ entry and interacts with ryanodine receptor (RyR), thereby influencing intracellular Ca2+ homeostasis through changes in the RyR/Ca2+ release function. Co-expression of SYPL2 and RyR in cultured cells leads to apoptotic cell death resulting from the depletion of Ca2+ from the intracellular stores.
    Gen-ID
    284612
    NCBI Accession
    NP_001035799
    UniProt
    Q5VXT5
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