MACC1 Antikörper (AA 430-480)

Produktnummer ABIN6991128

Produktdetails anti-MACC1 Antikörper

Target: MACC1 (Metastasis Associated in Colon Cancer 1 (MACC1))

Bindungsspezifität: AA 430-480

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MACC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Spezifität: At least two isoforms of MACC1 are known to exist.

Aufreinigung: MACC1 Antibody is affinity chromatography purified via peptide column.

Immunogen: MACC1 antibody was raised against a 17 amino acid synthetic peptide near the center of human MACC1. The immunogen is located within amino acids 430 - 480 of MACC1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: MACC1 antibody can be used for detection of MACC1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human and mouse samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: MACC1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: MACC1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu MACC1

Target: MACC1 (Metastasis Associated in Colon Cancer 1 (MACC1))

Andere Bezeichnung: MACC1 (MACC1 Produkte)

Synonyme: 7A5 antikoerper, SH3BP4L antikoerper, 4732474O15Rik antikoerper, Gm267 antikoerper, 7a5 antikoerper, RGD1309838 antikoerper, MACC1, MET transcriptional regulator antikoerper, metastasis associated in colon cancer 1 antikoerper, MACC1 antikoerper, Macc1 antikoerper

Hintergrund: MACC1 Antibody: Metastasis associated in colon cancer 1 (MACC1) is a key regulator of the hepatocyte growth factor (HGF)-HGF receptor (MET) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. MACC1 protein consists of four domains: ZU5, SH3, and two C-terminal death domains (DD). Expression of MACC1 was found significantly upregulated in malignant tissues (colon cancer of all stages as well as liver and lung metastases) compared to normal tissues or adenomas. MACC1 represents an early and crucial prognostic indicator for colon cancer metastasis that is independent of age, sex, tumor infiltration, nodal status, and lymph vessel invasion. Besides its involvement in signal transduction with the MET receptor, MACC1 also links MET signaling and apoptosis. MACC1 may also be an important therapeutic target for colorectal cancer treatment.

Molekulargewicht: Predicted: 94 kDa

Observed: 90 kDa

Gen-ID: 346389

NCBI Accession: NP_877439

UniProt: Q6ZN28