ADAM10 Antikörper (C-Term)

Produktnummer ABIN6991127

Der Kaninchen-Polyklonal Anti-ADAM10-Antikörper wurde für WB, ELISA, ICC und IF validiert. Er ist geeignet zum Nachweis von ADAM10 in Proben aus Human. }

Kurzübersicht für ADAM10 Antikörper (C-Term) (ABIN6991127)

Target: ADAM10 (ADAM Metallopeptidase Domain 10 (ADAM10))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ADAM10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Produktdetails anti-ADAM10 Antikörper

Bindungsspezifität: C-Term

Aufreinigung: ADAM10 Antibody is affinity chromatography purified via peptide column.

Immunogen: ADAM10 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human ADAM10. The immunogen is located within the last 50 amino acids of ADAM10.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ADAM10 can be used for detection of ADAM10 by Western blot at 1 - 2 μ,g/mL. This polyclonal antibody can also detect ADAM10 by immunohistochemistry at 2 μ,g/mL. For immunofluorescence start at 10 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: ADAM10 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: ADAM10 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu ADAM10

Target: ADAM10 (ADAM Metallopeptidase Domain 10 (ADAM10))

Andere Bezeichnung: ADAM10

Hintergrund: ADAM10 Antibody: Proinflammatory cytokine tumor necrosis factor-alpha (TNF-α,) contributes to a variety of inflammatory responses and programmed cell death. Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including a T-cell lymphoma. TNF-α, notch and its ligand delta are all membrane-bond molecules, which are cleaved by proteases to release mature proteins or functional receptor. ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), was recently identified to cleave TNF-α, notch and its ligand delta. The genes encoding human, mouse, and bovine ADAM10 were recently cloned and designated ADAM 10, kuzbanian (KUZ), and MADM, respectively. ADAM10 mRNA is expressed in a variety of human and bovine tissues.

Molekulargewicht: 85 kDa

Gen-ID: 102

NCBI Accession: NP_001101

UniProt: O14672

Pathways: Notch Signalweg, EGFR Signaling Pathway