TTBK2 Antikörper (C-Term)

Produktnummer ABIN6991063

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch TTBK2 in ELISA und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für TTBK2 Antikörper (C-Term) (ABIN6991063)

Target: TTBK2 (tau Tubulin Kinase 2 (TTBK2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TTBK2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-TTBK2 Antikörper

Bindungsspezifität: C-Term

Spezifität: TTBK2 antibody is human specific. At least four isoforms of TTBK2 are known to exist, this antibody will detect only the two largest isoforms.

Aufreinigung: TTBK2 Antibody is affinity chromatography purified via peptide column.

Immunogen: TTBK2 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human TTBK2. The immunogen is located within the last 50 amino acids of TTBK2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: TTBK2 antibody can be used for detection of TTBK2 by immunohistochemistry at 5 μ,g/mL.

Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: TTBK2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: TTBK2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu TTBK2

Target: TTBK2 (tau Tubulin Kinase 2 (TTBK2))

Andere Bezeichnung: TTBK2

Hintergrund: TTBK2 Antibody: Tau tubulin kinase (TTBK2) is a serine/threonine kinase whose substrates are thought to include the tau and tubulin proteins. Mutations in the TTBK2 gene cause spinocerebellar ataxia type 11 (SCA11), a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. Recent studies have shown that increased levels of TTBK2 expression in kidney carcinoma and melanoma cell lines increases resistance to the chemotherapeutic agent Sunitinib, and that reduction of TTBK2 though the use of siRNA sensitized these cell lines to the effects of Sunitib, suggesting that TTBK2 can be used as a resistance marker as well a potential target to overcome resistance.

Gen-ID: 146057

UniProt: Q6IQ55