PDCD5 Antikörper (N-Term)

Produktnummer ABIN6991062

Dieses Anti-PDCD5-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PDCD5 in WB, ELISA und ICC. Geeignet für Human, Maus und Ratte.

Kurzübersicht für PDCD5 Antikörper (N-Term) (ABIN6991062)

Target: PDCD5 (Programmed Cell Death 5 (PDCD5))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDCD5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Produktdetails anti-PDCD5 Antikörper

Bindungsspezifität: N-Term

Aufreinigung: PDCD5 Antibody is affinity chromatography purified via peptide column.

Immunogen: PDCD5 antibody was raised against a 13 amino acid synthetic peptide from near the amino terminus of human PDCD5. The immunogen is located within the first 50 amino acids of PDCD5.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: PDCD5 antibody can be used for detection of PDCD5 by Western blot at 2.5 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PDCD5 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: PDCD5 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu PDCD5

Target: PDCD5 (Programmed Cell Death 5 (PDCD5))

Andere Bezeichnung: PDCD5

Hintergrund: PDCD5 Antibody: Programmed cell death 5 (PDCD5), a human apoptosis-related protein, is thought to play an early and universal role in apoptosis. PDCD5 is widely expressed and is upregulated in cells undergoing apoptosis, where it translocates rapidly from the cytoplasm to the nucleus. PDCD5 has a compact core structure of low flexibility with two mobile alpha-helices at N-terminal and a flexible unstructured C-terminal region. The charged residues are crucial for the ability of apoptosis-promoting and cell translocation of the protein. PDCD5 can facilitate apoptosis and enhance TAJ/TROY-induced paraptosis-like cell death. PDCD5 may play a dual role in the Tip60 pathway. It interacts with Tip60 and functions as a Tip60 co-activator to promote apoptosis. The nucleotide polymorphisms in the 5'-upstream region of PDCD5 affect promoter activity and the susceptibility of a Chinese population to develop chronic myelogenous leukemia and may represent a novel tumor suppressor gene influencing lung cancer.

Molekulargewicht: Predicted: 14 kDa

Observed: 21 kDa

Gen-ID: 27347

UniProt: Q9UEW8