Junctophilin 2 Antikörper (C-Term)

Produktnummer ABIN6991018

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Junctophilin 2 in WB und ELISA. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für Junctophilin 2 Antikörper (C-Term) (ABIN6991018)

Target: Junctophilin 2 (JPH2)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Junctophilin 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-Junctophilin 2 Antikörper

Bindungsspezifität: AA 510-560, C-Term

Aufreinigung: JPH2 Antibody is affinity chromatography purified via peptide column.

Immunogen: JPH2 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human JPH2. The immunogen is located within amino acids 510 - 560 of JPH2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: JPH2 antibody can be used for detection of JPH2 by Western blot at 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: JPH2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: JPH2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu Junctophilin 2

Target: Junctophilin 2 (JPH2)

Andere Bezeichnung: JPH2

Hintergrund: JPH2 Antibody: Junctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/SR) are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. Junctophilins (JPs) are important components of the junctional complexes. JPs are composed of a carboxy-terminal hydrophobic segment spanning the ER/SR membrane and a remaining cytoplasmic domain that shows specific affinity for the PM. Four JPs have been identified as tissue-specific subtypes derived from different genes: JPH1 is expressed in skeletal muscle, JPH2 is detected throughout all muscle cell types, and JPH3 and JPH4 are predominantly expressed in the brain and contribute to the subsurface cistern formation in neurons. JPH2-null mice died of embryonic cardiac arrest and human patients with mutations in the JPH2 gene showed hypertrophic cardiomyopathy, demonstrating the importance of this protein. Multiple isoforms of JPH2 are known to exist.

Gen-ID: 84502

NCBI Accession: NP_065166

UniProt: Q96JJ6