ZNF350 Antikörper (C-Term)

Produktnummer ABIN6990987

Dieses Anti-ZNF350-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von ZNF350 in WB und ELISA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für ZNF350 Antikörper (C-Term) (ABIN6990987)

Target: ZNF350 (Zinc Finger Protein 350 (ZNF350))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZNF350 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-ZNF350 Antikörper

Bindungsspezifität: AA 410-460, C-Term

Aufreinigung: ZBRK1 Antibody is affinity chromatography purified via peptide column.

Immunogen: ZBRK1 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of the human ZBRK1. The immunogen is located within amino acids 410 - 460 of ZBRK1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ZBRK1 antibody can be used for detection of ZBRK1 by Western blot at 1 μ,g/mL.

Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: ZBRK1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: ZBRK1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu ZNF350

Target: ZNF350 (Zinc Finger Protein 350 (ZNF350))

Andere Bezeichnung: ZBRK1

Hintergrund: ZBRK1 Antibody: ZBRK1 is a member of the Kruppel-associated box-zinc finger protein (KRAB-ZFP) protein family of transcriptional repressors. ZBRK1 has been shown to not only be up-regulated in senescent fibroblasts but also interacts with BRCA1, a transcriptional regulator with tumor suppressor activity. ZBRK1 binds to a specific sequence within the GADD45 gene, supporting the assembly of a nuclear complex containing BRCA1 and repressing its transcription. Recent experiments demonstrate that ZBRK1 can homo-oligomerize in vitro and in vivo through a C-terminal transcriptional repression domain (CTRD), and this oligomerization facilitates the ZBRK1-directed transcriptional repression through ZBRK1 response elements. These results suggest that higher order ZBRK1 oligomers may assemble through both protein-DNA and CTRD-dependent protein-protein interactions.

Gen-ID: 59348

NCBI Accession: NP_067645

UniProt: Q9GZX5