Nanos Homolog 1 Antikörper (AA 160-210)

Produktnummer ABIN6990937

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Nanos Homolog 1 in WB, ELISA und IF. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für Nanos Homolog 1 Antikörper (AA 160-210) (ABIN6990937)

Target: Nanos Homolog 1 (NANOS1)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Nanos Homolog 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Produktdetails anti-Nanos Homolog 1 Antikörper

Bindungsspezifität: AA 160-210

Aufreinigung: Nanos1 Antibody is affinity chromatography purified via peptide column.

Immunogen: Nanos1 antibody was raised against a 14 amino acid synthetic peptide from near the center of human Nanos1. The immunogen is located within amino acids 160 - 210 of Nanos1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Nanos1 antibody can be used for detection of Nanos1 by Western blot at 1 - 2 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in rat samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Nanos1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: Nanos1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu Nanos Homolog 1

Target: Nanos Homolog 1 (NANOS1)

Andere Bezeichnung: Nanos1

Hintergrund: Nanos1 Antibody: Nanos1 is one of three known mammalian homologs to the Drosophila gene nanos. Nanos1 is an RNA-binding protein containing a zinc-finger motif and is expressed in the developing nervous system and continues in the adult brain. Interestingly, unlike mice deficient in either nanos2 or nanos3, mice lacking the nanos1 gene develop normally with no sign of abnormalities. Recently it has been found that expression of nanos1 mRNA is down-regulated by E-cadherin in a human breast cancer cell line and the amino-terminal domain on Nanos1 interacts with the E-cadherin-binding protein p120ctn. Furthermore, overexpression of Nanos1 in human colorectal DLD1 cancer cells functionally abolished cell-cell adhesion, allowing the cancer cells to develop strong migratory and invasive properties. These results suggest that targeting Nanos1 might prove an effective strategy in the treatment of E-cadherin-negative tumors.

Gen-ID: 340719

UniProt: Q8WY41

Pathways: Negative Regulation of Hormone Secretion, Myometrial Relaxation and Contraction