BICD1 Antikörper (C-Term)

Produktnummer ABIN6990932

Der Kaninchen Polyklonal Anti-BICD1-Antikörper wurde für WB, ELISA, IF und ICC validiert. Er ist geeignet, BICD1 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für BICD1 Antikörper (C-Term) (ABIN6990932)

Target: BICD1 (Bicaudal D Homolog 1 (BICD1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BICD1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Produktdetails anti-BICD1 Antikörper

Bindungsspezifität: C-Term

Spezifität: At least two isoforms of BICD1 are known to exist, this antibody will only recognize the larger isoform.

Aufreinigung: BICD1 Antibody is affinity chromatography purified via peptide column.

Immunogen: BICD1 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human BICD1. The immunogen is located within the last 50 amino acids of BICD1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: BICD1 antibody can be used for detection of BICD1 by Western blot at 1 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 10 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: BICD1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: BICD1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu BICD1

Target: BICD1 (Bicaudal D Homolog 1 (BICD1))

Andere Bezeichnung: BICD1

Hintergrund: BICD1 Antibody: BICD1 was initially identified as the human homolog to Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis. BICD1 can bind to dynein-dynactin and co-localizes with Rab6A on the trans-Golgi network and cytoplasmic vesicles, suggesting BICD1 regulates COPI-independent Golgi-ER transport. BICD1 will also interact with Rab6B, a Rab6 isoform that is expressed primarily in brain. Live cell imaging showed bi-directional movement of Rab6B structures in SK-N-SH neurites, indicating that BICD1 is involved in the Rab6B regulation of retrograde cargo transport in neuronal cells.

Gen-ID: 636

NCBI Accession: NP_001705

UniProt: Q96G01

Pathways: Ribonucleoprotein Complex Subunit Organization, Regulation of G-Protein Coupled Receptor Protein Signaling, Maintenance of Protein Location