RIMS2 Antikörper (AA 250-300)

Produktnummer ABIN6990907

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch RIMS2 in ELISA, WB, IHC (p) und IF. Es zeigt Reaktivität gegenüber Proben von Human, Ratte und Maus.

Kurzübersicht für RIMS2 Antikörper (AA 250-300) (ABIN6990907)

Target: RIMS2 (Regulating Synaptic Membrane Exocytosis 2 (RIMS2))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RIMS2 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Produktdetails anti-RIMS2 Antikörper

Bindungsspezifität: AA 250-300

Spezifität: Multiple isoforms of RIM2 are known to exist. This antibody is predicted to have no cross-reactivity to other Rim proteins.

Aufreinigung: Rim2 Antibody is affinity chromatography purified via peptide column.

Immunogen: Rim2 antibody was raised against a 17 amino acid synthetic peptide near the center of the human Rim2. The immunogen is located within amino acids 250 - 300 of Rim2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Rim2 antibody can be used for detection of Rim2 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rim2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: Rim2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu RIMS2

Target: RIMS2 (Regulating Synaptic Membrane Exocytosis 2 (RIMS2))

Andere Bezeichnung: Rim2

Hintergrund: Rim2 Antibody: Rab3-interacting molecules (RIMs) are synaptic proteins necessary for neuronal transmission and plasticity. Rim1 and Rim2 proteins are expressed in overlapping but distinct patterns throughout the brain. While the ablation of either gene was not lethal in mice, the deletion of both resulted in postnatal mortality. This lethality is due to a defect in neurotransmitter release, synapses without RIM proteins can still release neurotransmitters but are unable to do so in response to normal Ca2+ triggers. Like Rim1, Rim 2 is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner.

Molekulargewicht: Predicted: 39, 128, 148, 170 kDa

Observed: 128 kDa

Gen-ID: 9699

NCBI Accession: NP_001093587

UniProt: Q9UQ26

Pathways: Hormone Transport, Synaptic Vesicle Exocytosis