Transportin 3 Antikörper (N-Term)

Produktnummer ABIN6990902

Der Kaninchen Polyklonal Anti-Transportin 3-Antikörper wurde für ELISA und WB validiert. Er ist geeignet, Transportin 3 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für Transportin 3 Antikörper (N-Term) (ABIN6990902)

Target: Transportin 3 (TNPO3)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Transportin 3 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Produktdetails anti-Transportin 3 Antikörper

Bindungsspezifität: AA 140-190, N-Term

Aufreinigung: TNPO3 Antibody is affinity chromatography purified via peptide column.

Immunogen: TNPO3 antibody was raised against a 18 amino acid synthetic peptide from near the amino terminus of human TNPO3. The immunogen is located within amino acids 140 - 190 of TNPO3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: TNPO3 antibody can be used for detection of TNPO3 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: TNPO3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: TNPO3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu Transportin 3

Target: Transportin 3 (TNPO3)

Andere Bezeichnung: TNPO3

Hintergrund: TNPO3 Antibody: TNPO3 is a member of the importin beta/transportin family of nuclear import receptors and is specific for the essential splicing factors termed SR proteins, binding specifically and directly to the arginine/serine (RS)-rich domains of these proteins. Further experiments demonstrated that this interaction occurs only when these RS domains are phosphorylated. More recently, TNPO3 was identified as an HIV dependency factor (HDF) and that depletion of TNPO3 resulted in HIV inhibition after reverse transcription but before integration, suggesting that TNPO3 may be an important drug target in HIV treatment. At least three isoforms of TNPO3 are known to exist.

Molekulargewicht: Predicted: 105 kDa

Observed: 99 kDa

Gen-ID: 23534

UniProt: Q9Y5L0

Pathways: Protein targeting to Nucleus