TMC6 Antikörper (N-Term)

Produktnummer ABIN6990884

Der Kaninchen Polyklonal Anti-TMC6-Antikörper wurde für WB, ELISA und IHC (p) validiert. Er ist geeignet, TMC6 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für TMC6 Antikörper (N-Term) (ABIN6990884)

Target: TMC6 (Transmembrane Channel-Like 6 (TMC6))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TMC6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-TMC6 Antikörper

Bindungsspezifität: N-Term

Spezifität: At least four isoforms of EVER1 are known to exist. This EVER1 antibody does not cross-react with EVER2.

Aufreinigung: EVER1 Antibody is affinity chromatography purified via peptide column.

Immunogen: EVER1 antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus of human EVER1. The immunogen is located within the first 50 amino acids of EVER1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: EVER1 antibody can be used for the detection of EVER1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: EVER1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: EVER1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu TMC6

Target: TMC6 (Transmembrane Channel-Like 6 (TMC6))

Andere Bezeichnung: EVER1

Hintergrund: EVER1 Antibody: Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes, EVER1 and EVER2, located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. Both EVER1 and EVER2 are members of the transmembrane channel-like (TMC) protein family. EVER1 possesses eight trans-membrane domains and two leucine zipper motifs. EVER1 and EVER2 form a complex and interact with the zinc transporter 1 (ZnT-1), suggesting that EVER1 and EVER2 act to regulate cellular zinc balance.

Gen-ID: 11322

UniProt: Q7Z403