LGI4 Antikörper (AA 240-290)

Produktnummer ABIN6990873

Produktdetails anti-LGI4 Antikörper

Target: LGI4 (Leucine-Rich Repeat LGI Family, Member 4 (LGI4))

Bindungsspezifität: AA 240-290

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LGI4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: Two isoforms of LGI4 are known to exist, this LGI4 antibody will recognize only the larger form. This LGI4 antibody is predicted to be specific to LGI4 and not recognize other LGI proteins.

Aufreinigung: LGI4 Antibody is affinity chromatography purified via peptide column.

Immunogen: LGI4 antibody was raised against a 14 amino acid synthetic peptide from near the center of human LGI4. The immunogen is located within amino acids 240 - 290 of LGI4.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: LGI4 antibody can be used for the detection of LGI4 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: LGI4 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: LGI4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu LGI4

Target: LGI4 (Leucine-Rich Repeat LGI Family, Member 4 (LGI4))

Andere Bezeichnung: LGI4 (LGI4 Produkte)

Synonyme: Lgil3 antikoerper, clp antikoerper, LGIL3 antikoerper, leucine rich repeat LGI family member 4 antikoerper, leucine-rich repeat LGI family, member 4 antikoerper, LGI4 antikoerper, Lgi4 antikoerper

Hintergrund: LGI4 Antibody: The leucine-rich, glioma inactivated gene 4 (LGI4) is a member of the LGI family in which LGI1 is the exemplar. The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI4 have not been found to be associated with ADTLE. However, the LGI4 gene is located in a region linked to benign familial infantile convulsions. Further study revealed that a GC-to-AT polymorphism was correlated with childhood absence epilepsy. Other studies showed that decreasing LGI4 expression in cultured cells inhibits myelination, indicating that LGI4 may play a role in neural development.

Gen-ID: 163175

UniProt: Q8N135