LGI3 Antikörper (AA 390-440)

Produktnummer ABIN6990866

Der Kaninchen Polyklonal Anti-LGI3-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, LGI3 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für LGI3 Antikörper (AA 390-440) (ABIN6990866)

Target: LGI3 (Leucine-Rich Repeat LGI Family, Member 3 (LGI3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LGI3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-LGI3 Antikörper

Bindungsspezifität: AA 390-440

Spezifität: Two isoforms of LGI3 are known to exist, this LGI3 antibody will recognize both. This LGI3 antibody is predicted to be specific to LGI3 and not recognize other LGI proteins. The observed higher molecular weight band may represent a post-translationally modified form of LGI3.

Aufreinigung: LGI3 Antibody is affinity chromatography purified via peptide column.

Immunogen: LGI3 antibody was raised against a 12 amino acid synthetic peptide from near the center of human LGI3. The immunogen is located within amino acids 390 - 440 of LGI3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: LGI3 antibody can be used for the detection of LGI3 by Western blot at 1 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: LGI3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: LGI3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu LGI3

Target: LGI3 (Leucine-Rich Repeat LGI Family, Member 3 (LGI3))

Andere Bezeichnung: LGI3

Hintergrund: LGI3 Antibody: The leucine-rich, glioma inactivated gene 3 (LGI3) is a member of the LGI family in which LGI1 is the exemplar. The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI3 have not been found to be associated with ADTLE. LGI3 expression is induced in rat astrocyte cultures by the amyloid beta (Abeta) peptide and accumulated on neuronal plasma membranes of aged monkey brains and co-localized with Abeta.

Gen-ID: 203190

UniProt: Q8N145