FBXL20 Antikörper (C-Term)

Produktnummer ABIN6990847

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch FBXL20 in ELISA, WB und IHC (p). Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für FBXL20 Antikörper (C-Term) (ABIN6990847)

Target: FBXL20 (F-Box and Leucine-Rich Repeat Protein 20 (FBXL20))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FBXL20 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-FBXL20 Antikörper

Bindungsspezifität: C-Term

Aufreinigung: SCRAPPER Antibody is affinity chromatography purified via peptide column.

Immunogen: SCRAPPER antibody was raised against a 18 amino acid synthetic peptide near the carboxy terminus of the human SCRAPPER. The immunogen is located within the last 50 amino acids of SCRAPPER.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: SCRAPPER antibody can be used for detection of SCRAPPER by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: SCRAPPER Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: SCRAPPER antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu FBXL20

Target: FBXL20 (F-Box and Leucine-Rich Repeat Protein 20 (FBXL20))

Andere Bezeichnung: SCRAPPER

Hintergrund: SCRAPPER Antibody: Members of the F-box protein family, such as Scrapper, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases. Scrapper is selectively expressed in the brain, broadly expressed within the mouse CNS and is abundant at presynaptic membrane. Scrapper has orthologs in C. elegans, D. melanogaster, and mammals which suggests that it might function as an important membrane-localized E3 ligase in various species. Scrapper is a major presynaptic E3 ubiquitin ligase that acts through RIM1a via degradation and the ubiquitin-proteasome-system (UPS) pathway to critically regulate synaptic transmission. This identifies protein degradation as a mechanism for holding synaptic communication in check.

Gen-ID: 84961

NCBI Accession: NP_116264

UniProt: Q96IG2