TOCA-1 Antibody is affinity chromatography purified via peptide column.
Immunogen
TOCA-1 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of the human TOCA-1. The immunogen is located within amino acids 40 - 90 of TOCA-1.
FNBP1L
Reaktivität: Human
IF (cc), IF (p)
Wirt: Kaninchen
Polyclonal
AbBy Fluor® 647
Applikationshinweise
TOCA-1 antibody can be used for detection of TOCA-1 by Western blot at 0.5 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Konzentration
1 mg/mL
Buffer
TOCA-1 Antibody is supplied in PBS containing 0.02 % sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C,4 °C
Informationen zur Lagerung
TOCA-1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
C1orf39 antikoerper, TOCA1 antikoerper, 2610318I01Rik antikoerper, AW548221 antikoerper, RGD1305386 antikoerper, Toca-1 antikoerper, zgc:100923 antikoerper, toca1 antikoerper, toca-1 antikoerper, MGC132162 antikoerper, fnbp1l antikoerper, formin binding protein 1 like antikoerper, formin binding protein 1-like antikoerper, formin binding protein 1 like L homeolog antikoerper, formin binding protein 1 like S homeolog antikoerper, FNBP1L antikoerper, Fnbp1l antikoerper, fnbp1l antikoerper, fnbp1l.L antikoerper, fnbp1l.S antikoerper
Hintergrund
TOCA-1 Antibody: Actin reorganization is important for the regulation of neuronal morphology. A protein involved in this process, the transducer of cdc42-dependent actin assembly 1 (TOCA-1) protein, a member of the evolutionarily conserved pombe CDC15 homology (PCH) protein family, is an essential component of the Cdc42 pathway. TOCA-1 binds both N-WASP and Cdc42 and is essential for Cdc42- and PIP2-induced actin polymerization, suggesting that TOCA-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex. Decreased expression of TOCA-1 significantly enhances neurite elongation in PC-12 cells, its overexpression in the same cells suppresses neurite elongation. It has been suggested that TOCA-1 negatively regulates axon branching by regulating membrane trafficking by regulating membrane trafficking through the F-BAR/EFC domain. Multiple isoforms of TOCA-1 are known to exist.