CD248 Antikörper (N-Term)

Produktnummer ABIN6990809

Der Kaninchen Polyklonal Anti-CD248-Antikörper wurde für WB, ELISA, IHC (p) und IF validiert. Er ist geeignet, CD248 in Proben von Human zu detektieren.

Kurzübersicht für CD248 Antikörper (N-Term) (ABIN6990809)

Target: CD248 (CD248 Molecule, Endosialin (CD248))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CD248 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Produktdetails anti-CD248 Antikörper

Bindungsspezifität: AA 40-90, N-Term

Spezifität: At least two isoforms of TEM1 are known to exist, this antibody recognizes only the larger isoform.

Aufreinigung: TEM1 Antibody is affinity chromatography purified via peptide column.

Immunogen: Anti-TEM-1 antibody was raised against a peptide corresponding to 14 amino acids near the amino terminus of human TEM-1. The immunogen is located within amino acids 40-90 of TEM-1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 0.5-2 μ,g/mL, IHC-P: 2.5 μ,g/mL, IF: 20 μ,g/mL.

Antibody validated: Western Blot in human and mouse samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: TEM1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: TEM1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu CD248

Target: CD248 (CD248 Molecule, Endosialin (CD248))

Andere Bezeichnung: TEM1

Hintergrund: TEM1 Antibody: Tumor endothelial marker (TEM) 1 was originally identified as a human embryonic fibroblast-specific antigen and was later determined to be endosialin, a single-pass transmembrane glycoprotein that has multiple extracellular domains, including three EGF-like domains, a sushi-like domain, and a C lectin-like domain. TEM proteins are significantly up-regulated during angiogenesis and neoangiogenesis that are crucial for the growth of solid tumors. While TEM1 is not required for angiogenesis during fetal development, postnatal growth or wound healing, it plays a role in tumor growth, invasion, and metastasis. Fibronectin and collagen types I and IV act as specific ligands of TEM1, leading to suggestions that these molecules may cause changes in the extracellular matrix, cell adhesion and migration during tumor invasion.

Molekulargewicht: Predicted: 81kD

Observed: 90 kD (post-modifications: 27 O-linked glycosylations) kDa

Gen-ID: 57124

NCBI Accession: NP_065137

UniProt: Q9HCU0