STEAP1 Antikörper (AA 130-180)

Produktnummer ABIN6990785

Der Kaninchen Polyklonal Anti-STEAP1-Antikörper wurde für WB, ELISA, IHC (p) und IF validiert. Er ist geeignet, STEAP1 in Proben von Human, Ratte und Maus zu detektieren.

Kurzübersicht für STEAP1 Antikörper (AA 130-180) (ABIN6990785)

Target: STEAP1 (Six Transmembrane Epithelial Antigen of The Prostate 1 (STEAP1))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STEAP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Produktdetails anti-STEAP1 Antikörper

Bindungsspezifität: AA 130-180

Spezifität: This STEAP1 antibody does not cross-react with other STEAP proteins.

Aufreinigung: STEAP1 Antibody is affinity chromatography purified via peptide column.

Immunogen: STEAP1 antibody was raised against a 16 amino acid synthetic peptide from near the center of human STEAP1. The immunogen is located within amino acids 130 - 180 of STEAP1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: STEAP1 antibody can be used for detection of STEAP1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL. better

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: STEAP1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: STEAP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu STEAP1

Target: STEAP1 (Six Transmembrane Epithelial Antigen of The Prostate 1 (STEAP1))

Andere Bezeichnung: STEAP1

Hintergrund: STEAP1 Antibody: The six-transmembrane epithelial antigen of prostate 1 (STEAP1) was the first member of a family of metalloreductases identified as cell-surface antigens in prostate tissue. The normal function of STEAP is still uncertain, unlike other members of the STEAP family, STEAP1 does not promote iron or copper reduction or uptake and lacks the FNO-like reductase domain critical for activity. However, its expression is highly increased in multiple cancer cell lines, including prostate, bladder, colon, and ovarian cancers. Supporting this is evidence that STEAP1 peptides can be used to stimulate CD8+ T cells from healthy donors, enabling them to recognize STEAP1-positive human tumor cells, suggesting that STEAP1 may a potential target for cancer immunotherapy. At least three isoforms of STEAP1 are known to exist.

Gen-ID: 26872

UniProt: Q9UHE8

Pathways: Transition Metal Ion Homeostasis