FYB Antikörper (N-Term)

Produktnummer ABIN6990773

Der Kaninchen Polyklonal Anti-FYB-Antikörper wurde für WB, ELISA, ICC und IF validiert. Er ist geeignet, FYB in Proben von Human zu detektieren.

Kurzübersicht für FYB Antikörper (N-Term) (ABIN6990773)

Target: FYB (FYN-Binding Protein (FYB))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FYB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Produktdetails anti-FYB Antikörper

Bindungsspezifität: AA 60-110, N-Term

Aufreinigung: ADAP Antibody is affinity chromatography purified via peptide column.

Immunogen: ADAP antibody was raised against a 17 amino acid synthetic peptide from near the amino terminus of human ADAP. The immunogen is located within amino acids 60 - 110 of ADAP.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ADAP antibody can be used for detection of ADAP by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: ADAP Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: ADAP antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu FYB

Target: FYB (FYN-Binding Protein (FYB))

Andere Bezeichnung: ADAP

Hintergrund: ADAP Antibody: The adhesion and degranulation adaptor protein (ADAP) was initially identified as a molecular adapter that couples T cell receptor (TCR) stimulation to the avidity of integrins governing T cell adhesion. TCR stimulation promotes the formation of a multi-protein complex containing CARMA1, MALT1, and BCL-10, which through the association of ADAP, ultimately activates the NF-κ,B family of transcription factors. More recent experiments have shown that ADAP controls optimal T cell proliferation, cytokine production, and expression of the Bcl-2 family member Bcl-x(L), suggesting that ADAP regulates T cell activation by promoting antigen-dependent T cell-antigen presenting cell (APC) activation. At least three isoforms of ADAP are known to exist.

Gen-ID: 2533

NCBI Accession: NP_001456

UniProt: O15117

Pathways: T-Zell Rezeptor Signalweg, Protein targeting to Nucleus