NRN1 Antikörper (AA 70-120)

Produktnummer ABIN6990738

Der Kaninchen Polyklonal anti-NRN1 Antikörper (ABIN6990738) detektiert spezifisch NRN1 in ELISA, WB, IHC (p) und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für NRN1 Antikörper (AA 70-120) (ABIN6990738)

Target: NRN1 (Neuritin 1 (NRN1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NRN1 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Produktdetails anti-NRN1 Antikörper

Bindungsspezifität: AA 70-120

Aufreinigung: Neuritin Antibody is affinity chromatography purified via peptide column.

Immunogen: Neuritin antibody was raised against a 20 amino acid synthetic peptide from near the center of human neuritin. The immunogen is located within amino acids 70 - 120 of Neuritin.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Neuritin antibody can be used for detection of Neuritin by Western blot at 5 and 10 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human and mouse samples and Immunofluorescence in human and mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Neuritin Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: Neuritin antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu NRN1

Target: NRN1 (Neuritin 1 (NRN1))

Andere Bezeichnung: Neuritin

Hintergrund: Neuritin Antibody: As the nervous system of a complex organism develops, it establishes functional networks through the growth and retraction of synaptic connections from growing axons and dendrites. This synaptic remodeling involves neuro-transmitter signaling, activation of neurotrophin receptors and alterations in gene expression. One such gene whose expression is increased by neural activity is neuritin, a GPI-anchored protein that is expressed in postmitotic differentiating neurons of the developing nervous system. Its expression is also induced by the neurotrophins BDNF and NT-3. Purified recombinant neuritin promotes neurite outgrowth and arborization in primary embryonic neuronal cultures, suggesting that neuritin may play a role as a downstream effector of activity-induced neurite outgrowth. More recent experiments have shown that neuritin is required for the androgen-induced axonal elongation in motor neurons and is upregulated following spinal cord injury, suggesting that neuritin may also play a role in survival and axonal regeneration.

Molekulargewicht: Predicted: 16 kDa

Observed: 15 kDa

Gen-ID: 51299

NCBI Accession: NP_057672

UniProt: Q9NPD7