Der Kaninchen Polyklonal anti-SAMHD1 Antikörper wird verwendet zum Nachweis von SAMHD1 in Proben von Human und Maus. Er wurde validiert für WB, ELISA, IF und IHC.
Phospho-SAMHD1 antibody will only detect the phosphorylated form of SAMHD1.
Aufreinigung
SAMHD1 (phospho Thr592) antibody is affinity chromatography purified via peptide column.
Immunogen
Anti-SAMHD1 (phospho Thr592) antibody was raised against a phosphorylated peptide corresponding to 18 amino acids near the carboxy terminus of human Phospho-SAMHD1 surrounding T592.
Antibody validated: Western Blot in human and mouse samples, Immunohistochemistry and Immunofluorescence in human samples. All other applications and species not yet tested.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Konzentration
1 mg/mL
Buffer
SAMHD1 (phospho Thr592) antibody is supplied in PBS containing 0.02 % sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C,4 °C
Informationen zur Lagerung
SAMHD1 (phospho Thr592) antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Target
SAMHD1
(SAM Domain and HD Domain 1 (SAMHD1))
Andere Bezeichnung
SAMHD1
Hintergrund
The SAM domain and HD domain 1 (SAMHD1) protein is upregulated in response to viral infection and is thought to play a role in innate immunity (1). SAMHD1 blocks the infection of HIV-1 and SIVdeltaVpx before reverse transcription in macrophages and dendritic cells (2), and this restriction is regulated by phosphorylation of SAMHD1 (3). Mutations in this gene have been associated with Aicardi-Goutieres syndrome (1).