Nicastrin Antikörper (AA 370-420)

Produktnummer ABIN6990692

Produktdetails anti-Nicastrin Antikörper

Target: Nicastrin (NCSTN)

Bindungsspezifität: AA 370-420

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Nicastrin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Nicastrin Antibody is affinity chromatography purified via peptide column.

Immunogen: Nicastrin antibody was raised against a 18 amino acid synthetic peptide from near the center of human Nicastrin. The immunogen is located within amino acids 370 - 420 of Nicastrin.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Nicastrin antibody can be used for detection of Nicastrin by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human and mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Nicastrin Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: Nicastrin antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu Nicastrin

Target: Nicastrin (NCSTN)

Andere Bezeichnung: Nicastrin (NCSTN Produkte)

Synonyme: CG7012 antikoerper, Dmel\\CG7012 antikoerper, Nct antikoerper, Nic antikoerper, S5A antikoerper, ST96B antikoerper, agro antikoerper, dNct antikoerper, nic antikoerper, NCSTN antikoerper, DKFZp469O2418 antikoerper, APH2 antikoerper, 9430068N19Rik antikoerper, AA727311 antikoerper, Aph2 antikoerper, D1Dau13e antikoerper, Kiaa0253 antikoerper, mKIAA0253 antikoerper, nicastrin antikoerper, Nicastrin antikoerper, NCSTN antikoerper, nct antikoerper, ncstn antikoerper, CpipJ_CPIJ001617 antikoerper, Ncstn antikoerper, aph-2 antikoerper

Hintergrund: Nicastrin Antibody: Nicastrin, in addition to presenilin, PEN2, and APH-1 forms the gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease. Like the tumor necrosis factor-alpha-converting enzyme (TACE) and the beta-site cleavage enzyme (BACE) protease families, gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the alpha and gamma cleavage site) or the toxic Abeta amyloid peptide (from the beta and gamma cleavage site). It is thought that accumulation of the Abeta peptide is the precursor to Alzheimer's disease. Nicastrin is also thought to be involved in cell proliferation and signaling, especially in regards to activation of Notch receptors as loss of Nicastrin expression results in mouse embryonic lethality.

Gen-ID: 23385

NCBI Accession: NP_056146

UniProt: Q92542

Pathways: Notch Signalweg, Neurotrophin Signalübertragung