BCL2A1 Antikörper (C-Term)

Produktnummer ABIN6990657

Produktdetails anti-BCL2A1 Antikörper

Target: BCL2A1 (BCL2-Related Protein A1 (BCL2A1))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BCL2A1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Spezifität: At least two isoforms of Bfl-1 are known to exist, this antibody will only detect the larger isoform.

Aufreinigung: Bfl-1 Antibody is affinity chromatography purified via peptide column.

Immunogen: Bfl-1 antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human Bfl-1. The immunogen is located within the last 50 amino acids of Bfl-1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Bfl-1 antibody can be used for the detection of Bfl-1 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Bfl-1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: Bfl-1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu BCL2A1

Target: BCL2A1 (BCL2-Related Protein A1 (BCL2A1))

Andere Bezeichnung: Bfl-1 (BCL2A1 Produkte)

Synonyme: ACC-1 antikoerper, ACC-2 antikoerper, BCL2L5 antikoerper, BFL1 antikoerper, GRS antikoerper, HBPA1 antikoerper, Bcl2a1d antikoerper, BCL2A1 antikoerper, BCL2 related protein A1 antikoerper, BCL2-related protein A1 antikoerper, BCL2A1 antikoerper, Bcl2a1 antikoerper

Hintergrund: Bfl-1 Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells and is caused by caspase activation. Proteins that comprise the Bcl-2 family appear to control the activation of these enzymes. One such member is multi-domain antiapoptotic protein Bfl-1, which is overexpressed in stomach and other cancers. Bfl-1 can interact with Bax and suppress apoptosis by inhibiting the release of cytochrome c and caspase-3 activation. It is upregulated in cisplatin-resistant human bladder tumors, suggesting that its expression may be important for cisplatin resistance and inhibition of apoptosis in cancer cells.

Molekulargewicht: Predicted: 19 kDa

Observed: 20 kDa

Gen-ID: 597

NCBI Accession: NP_004040

UniProt: Q16548