IL-27 Antikörper (N-Term)

Produktnummer ABIN6990633

Dieses Anti-IL-27-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von IL-27 in WB, ELISA und ICC. Geeignet für Human und Maus.

Kurzübersicht für IL-27 Antikörper (N-Term) (ABIN6990633)

Target: IL-27 (IL27) (Interleukin 27 (IL27))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL-27 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Produktdetails anti-IL-27 Antikörper

Bindungsspezifität: N-Term

Aufreinigung: IL-27 Antibody is affinity chromatography purified via peptide column.

Immunogen: Anti-IL-27 antibody was raised against a peptide corresponding to 16 amino acids near the amino terminus of human IL-27. The immunogen is located within the first 50 amino acids of IL-27.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 0.5 - 4 μ,g/mL, ICC: 10 μ,g/mL.

Antibody validated: Western Blot in human and mouse samples, Immunocytochemistry in mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: IL-27 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: IL-27 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu IL-27

Target: IL-27 (IL27) (Interleukin 27 (IL27))

Andere Bezeichnung: IL-27

Hintergrund: IL-27 Antibody: Like interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naive but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-gamma, and T-bet.

Molekulargewicht: Predicted: 28 kDa

Observed: 28 kDa

Gen-ID: 246778

NCBI Accession: NP_663634

UniProt: Q8NEV9