IL-31 Antikörper (AA 60-110)

Produktnummer ABIN6990613

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch IL-31 in WB, ELISA und IF. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für IL-31 Antikörper (AA 60-110) (ABIN6990613)

Target: IL-31 (IL31) (Interleukin 31 (IL31))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL-31 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Produktdetails anti-IL-31 Antikörper

Bindungsspezifität: AA 60-110

Aufreinigung: IL-31 Antibody is affinity chromatography purified via peptide column.

Immunogen: IL-31 antibody was raised against a 18 amino acid synthetic peptide from near the center of human IL-31. The immunogen is located within amino acids 60 - 110 of IL-31.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IL-31 antibody can be used for the detection of IL-31 by Western blot at 2.5 - 10 μ,g/mL. Despite its predicted size, IL-31 runs at approximately 27 - 30 kDa in SDS-PAGE. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: IL-31 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: IL-31 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu IL-31

Target: IL-31 (IL31) (Interleukin 31 (IL31))

Andere Bezeichnung: IL-31

Hintergrund: IL-31 Antibody: Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development.

Gen-ID: 386653

UniProt: Q6EBC2