DRAM Antikörper (C-Term)

Produktnummer ABIN6990601

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch DRAM in WB, ELISA, IHC (p) und IF. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für DRAM Antikörper (C-Term) (ABIN6990601)

Target: DRAM (DRAM1) (DNA-Damage Regulated Autophagy Modulator 1 (DRAM1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DRAM Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Produktdetails anti-DRAM Antikörper

Bindungsspezifität: AA 170-220, C-Term

Aufreinigung: DRAM Antibody is affinity chromatography purified via peptide column.

Immunogen: Anti-DRAM antibody was raised against a peptide corresponding to 16 amino acids near the carboxy terminus of human DRAM. The immunogen is located within amino acids 170-220 of DRAM.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1 μ,g/mL, IF: 20 μ,g/mL, IHC: 2.5 μ,g/mL.

Antibody validated: Western Blot in human, mouse and rat samples, Immunofluorescence and Immunohistochemistry in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: DRAM Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: DRAM antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu DRAM

Target: DRAM (DRAM1) (DNA-Damage Regulated Autophagy Modulator 1 (DRAM1))

Andere Bezeichnung: DRAM

Hintergrund: DRAM Antibody: Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. It has been suggested that activation of DRAM by p53 is simultaneous to the activation by p53 of one or more proapoptotic genes such as PUMA, Bax, etc., and that the signaling pathways regulated by these genes promote a full cell death response. By itself, DRAM cannot induce apoptosis, but the fact that it is inactivated in certain cancers highlights the importance of DRAM and suggests that autophagy may play a more important role in cancer than initially suspected. At least two different isoforms of DRAM are known to exist.

Molekulargewicht: Predicted: 14kD, 26kD

Observed: 14 kD, 26kD kDa

Gen-ID: 55332

UniProt: Q8N682