GOPC Antikörper (C-Term)

Produktnummer ABIN6990581

Der Kaninchen Polyklonal Anti-GOPC-Antikörper wurde für WB, ELISA, IF und IHC (p) validiert. Er ist geeignet, GOPC in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für GOPC Antikörper (C-Term) (ABIN6990581)

Target: GOPC (Golgi-Associated PDZ and Coiled-Coil Motif Containing (GOPC))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GOPC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-GOPC Antikörper

Bindungsspezifität: AA 360-410, C-Term

Aufreinigung: PIST Antibody is affinity chromatography purified via peptide column.

Immunogen: PIST antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human PIST. The immunogen is located within amino acids 360 - 410 of PIST.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: PIST antibody can be used for the detection of PIST by Western blot at 1 - 4 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2 μ,g/mL. For immunofluorescence start at 10 μ,g/mL.

Antibody validated: Western Blot in rat samples, Immunohistochemistry in human and rat samples and Immunofluorescence in human and rat samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PIST Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: PIST antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu GOPC

Target: GOPC (Golgi-Associated PDZ and Coiled-Coil Motif Containing (GOPC))

Andere Bezeichnung: PIST

Hintergrund: PIST Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components and is negatively regulated by TOR (Target of rapamycin). PIST, a PDZ-containing protein, was discovered in a yeast two-hybrid system as a binding partner to Beclin-1, a Bcl-2-interacting protein homologous to the yeast autophagy gene apg6. Experiments with mutant PIST proteins lacking the PDZ domain showed that PIST interaction with Beclin-1 through its coiled-coil domain can modulate Beclin-1 activity and suggest that PIST interactions with other proteins through its PDZ domain may regulate the activity of PIST and Beclin-1.

Gen-ID: 57120

UniProt: Q9HD26

Pathways: Maintenance of Protein Location, Asymmetric Protein Localization