BACE1 Antikörper (C-Term)

Produktnummer ABIN6990574

Produktdetails anti-BACE1 Antikörper

Target: BACE1 (Beta-secretase 1 (BACE1))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BACE1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Immunocytochemistry (ICC)

Aufreinigung: BACE Antibody is Ion exchange chromatography purified.

Immunogen: Anti-BACE antibody was raised against a peptide corresponding to 17 amino acids near the carboxy terminus of human BACE. The immunogen is located within the last 50 amino acids of BACE.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1 μ,g/mL, IHC-P: 2.5 μ,g/mL, ICC: 10 μ,g/mL, IF: 20 μ,g/mL.

Antibody validated: Western Blot in human and mouse samples, Immunohistochemistry, Immunocytochemistry and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: BACE Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: BACE antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu BACE1

Target: BACE1 (Beta-secretase 1 (BACE1))

Andere Bezeichnung: BACE (BACE1 Produkte)

Synonyme: ASP2 antikoerper, BACE antikoerper, HSPC104 antikoerper, C76936 antikoerper, Bace antikoerper, MGC145931 antikoerper, BACE1 antikoerper, zgc:77409 antikoerper, beta-secretase 1 antikoerper, beta-site APP cleaving enzyme 1 antikoerper, beta-site APP-cleaving enzyme 1 antikoerper, BACE1 antikoerper, Bace1 antikoerper, bace1 antikoerper

Hintergrund: BACE Antibody: Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by two proteases. APP is first cleaved by beta-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma-secretase to generate the 4 kDa amyloid-beta peptide, which is deposited in the brains of all suffers of Alzheimer's disease. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). BACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP.

Molekulargewicht: Predicted: 55kD

Observed: 65kD (Post-modification: 4 N-linked glycosylation) kDa

Gen-ID: 23621

UniProt: P56817