TNFSF18 Antikörper

Produktnummer ABIN6990563

Produktdetails anti-TNFSF18 Antikörper

Target: TNFSF18 (Tumor Necrosis Factor (Ligand) Superfamily, Member 18 (TNFSF18))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TNFSF18 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Aufreinigung: GITRL Antibody is affinity chromatography purified via peptide column.

Immunogen: GITRL antibody was raised against purified recombinant human GITR ligand.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: GITRL antibody can be used for the detection of GITRL by Western blot at 1 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL.

Antibody validated: Immunocytochemistry in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: GITRL Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: GITRL antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu TNFSF18

Target: TNFSF18 (Tumor Necrosis Factor (Ligand) Superfamily, Member 18 (TNFSF18))

Andere Bezeichnung: GITRL (TNFSF18 Produkte)

Synonyme: Gitrl antikoerper, AITRL antikoerper, GITRL antikoerper, TL6 antikoerper, hGITRL antikoerper, TNLG2A antikoerper, tumor necrosis factor (ligand) superfamily, member 18 antikoerper, TNF superfamily member 18 antikoerper, Tnfsf18 antikoerper, TNFSF18 antikoerper

Hintergrund: GITRL Antibody: The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-κ,B and various mitogen-activated protein kinases. The glucocorticoid-induced tumor necrosis factor receptor (GITR) is an emerging member of this family that is expressed on CD4+ CD25+ regulatory T cells and appears to have crucial immune regulation functions. Its ligand GITRL is expressed in endothelial and antigen-presenting cells and can activate NF-κ,B, induce both pro- and anti-apoptotic effects, inhibit the suppressive activity of regulatory T cells, and co-stimulate responder T cells through GITR. Dominant negative forms of NIK and TRAF2 expressed in transfected 293 cells substantially inhibited NF-κ,B activation, suggesting that the GITRL-GITR pathway involves both NIK and TRAF2.

Gen-ID: 8995

UniProt: Q9UNG2