Anthrax Toxin Lethal Factor Antikörper (AA 420-470)

Produktnummer ABIN6990498

Dieses Anti-Anthrax Toxin Lethal Factor-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Anthrax Toxin Lethal Factor in ELISA. Geeignet für Bacillus anthracis.

Kurzübersicht für Anthrax Toxin Lethal Factor Antikörper (AA 420-470) (ABIN6990498)

Target: Anthrax Toxin Lethal Factor (Lef)

Reaktivität: Bacillus anthracis

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Anthrax Toxin Lethal Factor Antikörper ist unkonjugiert

Applikation: ELISA

Produktdetails anti-Anthrax Toxin Lethal Factor Antikörper

Bindungsspezifität: AA 420-470

Aufreinigung: Anthrax Lethal Factor Antibody is affinity chromatography purified via peptide column.

Immunogen: Anthrax lethal factor antibody was raised against a synthetic peptide corresponding to 16 amino acids in the middle of the Anthrax lethal factor protein. The immunogen is located within amino acids 420 - 470 of Anthrax Lethal Factor.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Anthrax lethal factor antibody can be used for the detection of Anthrax LF protein in ELISA. It will detect 10 ng of free peptide at 1 μ,g/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Anthrax Lethal Factor Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: Anthrax Lethal Factor antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu Anthrax Toxin Lethal Factor

Target: Anthrax Toxin Lethal Factor (Lef)

Andere Bezeichnung: Anthrax Lethal Factor

Hintergrund: Anthrax Lethal Factor Antibody: Anthrax infection is initiated by the inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin: protective antigen (PA), lethal factor (LF), and edema factor (EF). PA binds to two related proteins on the cell surface, these are termed tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR) and capillary morphogenesis protein 2 (CMG2), although it is still unclear which is physiologically relevant. Following PA binding to its receptor, PA is cleaved into two fragments by a furin-like protease. The bound fragment binds both LF and EF, the resulting complex is then endocytosed which allows the translocation of LF and EF into the cytoplasm. LF is the primary toxin of anthrax and functions as a highly specific protease that cleaves members of the mitogen-activated protein kinase kinase (MAPKK) family near their amino terminus, interfering with MAPK signaling and inducing apoptosis.

Gen-ID: 3361711

UniProt: P15917