IRF8 Antikörper (C-Term)

Produktnummer ABIN6990493

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch IRF8 in WB, ELISA und IF. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für IRF8 Antikörper (C-Term) (ABIN6990493)

Target: IRF8 (Interferon Regulatory Factor 8 (IRF8))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IRF8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Produktdetails anti-IRF8 Antikörper

Bindungsspezifität: C-Term

Aufreinigung: IRF8 Antibody is affinity chromatography purified via peptide column.

Immunogen: IRF8 antibody was raised against a peptide corresponding to 16 amino acids near the carboxy terminus of human IRF8. The immunogen is located within the last 50 amino acids of IRF8.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IRF8 antibody can be used for detection of IRF8 by Western blot at 1 μ,g/mL. For immunofluorescence start at 10 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: IRF8 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: IRF8 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu IRF8

Target: IRF8 (Interferon Regulatory Factor 8 (IRF8))

Andere Bezeichnung: IRF8

Hintergrund: IRF8 Antibody: Interferons (IFN)s are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. Unlike IRF3, IRF8 appears to act as a negative regulator of IFN-induced genes in most cases, but IRF8 mediates activation of NF-κ,B by the toll-like receptor 9 (TLR9) after stimulation by unmethylated CpG DNA in dendritic cells. Finally, it has been shown that IRF8 decreases bcl-2 expression and thus may play a role in chronic myelogenous leukemia.

Gen-ID: 3394

UniProt: Q02556

Pathways: Cellular Response to Molecule of Bacterial Origin