HTRA2 Antikörper (N-Term)

Produktnummer ABIN6990466

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch HTRA2 in WB, ELISA, IF und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für HTRA2 Antikörper (N-Term) (ABIN6990466)

Target: HTRA2 (HtrA Serine Peptidase 2 (HTRA2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HTRA2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-HTRA2 Antikörper

Bindungsspezifität: AA 120-170, N-Term

Aufreinigung: OMI Antibody is Ion exchange chromatography purified.

Immunogen: OMI antibody was raised against a peptide corresponding to 15 amino acids near the N-terminus of human OMI. The immunogen is located within amino acids 120 - 170 of OMI.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: OMI antibody can be used for detection of OMI by Western blot at 0.5 to 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: OMI Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: OMI antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu HTRA2

Target: HTRA2 (HtrA Serine Peptidase 2 (HTRA2))

Andere Bezeichnung: OMI

Hintergrund: OMI Antibody: Inhibitor of apoptosis proteins (IAPs) were initially identified in baculoviruses as proteins that inhibit apoptosis of the host cells to allow time for viral replication. Cellular homologues containing at least one baculoviral IAP repeat (BIR) motif essential for their anti-apoptosis activity have been identified in yeasts and higher organisms and often act by binding and inhibiting processed caspases. The activity of these proteins can be modulated by the expression of proteins such as Smac/DIABLO and XAF-1 which displace or prevent the binding of caspases by IAPs. Recently, a mitochondrial serine protease termed Omi/HtrA2 has been found to bind IAPs. Similar to Smac, Omi possesses a conserved IAP-binding motif, but acts to cleave IAPs to irreversibly inactivate IAPs and promote apoptosis.

Gen-ID: 27429

UniProt: O43464

Pathways: Positive Regulation of Endopeptidase Activity