CARD14 Antikörper (C-Term)

Produktnummer ABIN6990437

Der Kaninchen Polyklonal Anti-CARD14-Antikörper wurde für ELISA und IHC (p) validiert. Er ist geeignet, CARD14 in Proben von Human zu detektieren.

Kurzübersicht für CARD14 Antikörper (C-Term) (ABIN6990437)

Target: CARD14 (Caspase Recruitment Domain Family, Member 14 (CARD14))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CARD14 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-CARD14 Antikörper

Bindungsspezifität: C-Term

Spezifität: CARMA2 antibody is human specific. At least three isoforms of CARMA2 are known to exist, this antibody will only detect isoform 1. CARMA2 antibody is predicted not to cross-react with other CARMA proteins.

Aufreinigung: CARMA2 Antibody is affinity chromatography purified via peptide column.

Immunogen: CARMA2 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human CARMA2. The immunogen is located within the last 50 amino acids of CARMA2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: CARMA2 antibody can be used for detection of CARMA2 by immunohistochemistry at 5 μ,g/mL.

Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: CARMA2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: CARMA2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu CARD14

Target: CARD14 (Caspase Recruitment Domain Family, Member 14 (CARD14))

Andere Bezeichnung: CARMA2

Hintergrund: CARMA2 Antibody: CARMA proteins belong to the membrane-associated guan-ylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. As with CARMA1, the CARD domain of CARMA2 has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-κ,B activation. When expressed in cells, this protein activated NF-κ,B and induced the phosphorylation of BCL10 Alternative splicing of CARMA2 results in isoforms that possess differential effects on NF-κ,B activation and endoplasmic reticulum stress-induced cell death.

Gen-ID: 79092

NCBI Accession: NP_077015

UniProt: Q9BXL6