CARD8 Antikörper (C-Term)

Produktnummer ABIN6990435

Produktdetails anti-CARD8 Antikörper

Target: CARD8 (Caspase Recruitment Domain Family, Member 8 (CARD8))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CARD8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Aufreinigung: CARD8 Antibody is affinity chromatography purified via peptide column.

Immunogen: CARD8 antibody was raised against a synthetic peptide corresponding to amino acids at the C-terminus of human CARD8. The immunogen is located within the last 50 amino acids of CARD8.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: CARD8 antibody can be used for detection of CARD8 by Western blot at 1 -2 μ,g/mL. An approximate 45 kDa can be detected. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: CARD8 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: CARD8 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu CARD8

Target: CARD8 (Caspase Recruitment Domain Family, Member 8 (CARD8))

Andere Bezeichnung: CARD8 (CARD8 Produkte)

Synonyme: CARD8 antikoerper, CARDINAL antikoerper, DACAR antikoerper, DAKAR antikoerper, NDPP antikoerper, NDPP1 antikoerper, TUCAN antikoerper, caspase recruitment domain family, member 8 antikoerper, caspase recruitment domain-containing protein 8 antikoerper, caspase recruitment domain family member 8 antikoerper, CARD8 antikoerper, LOC718594 antikoerper

Hintergrund: CARD8 Antibody: Apoptosis is related to many diseases and development. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. CARD containing proteins include some caspases, Apaf-1, CARD4, IAPs, RICK, ARC, RAIDD, BCL-10, and ASC. A novel CARD-containing protein was recently identified and designated CARD8. This protein interacts with DRAL, a p53-responsive protein implicated in the induction of apoptosis, and caspase-1 and its related proteins ICEBERG and pesudo-ICE. Although there are conflicting reports on whether CARD8 acts a pro- or anti-apoptotic protein, it has been suggested that it functions as an adaptor molecule regulating caspase-1 and NF-κ,B activation.

Molekulargewicht: Predicted: 47 kDa

Observed: 47 kDa

Gen-ID: 22900

UniProt: Q9Y2G2

Pathways: Positive Regulation of Endopeptidase Activity