DEDD2 Antikörper (N-Term)

Produktnummer ABIN6990411

Dieses Anti-DEDD2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von DEDD2 in WB und ELISA. Geeignet für Human, Ratte und Maus.

Kurzübersicht für DEDD2 Antikörper (N-Term) (ABIN6990411)

Target: DEDD2 (Death Effector Domain Containing 2 (DEDD2))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DEDD2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-DEDD2 Antikörper

Bindungsspezifität: N-Term

Aufreinigung: DEDD2 Antibody is immunoaffinity chromatography purified IgG.

Immunogen: DEDD2 antibody was raised against a peptide corresponding to 11 amino acids near the amino-terminus of human DEDD2. The immunogen is located within the first 50 amino acids of DEDD2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: DEDD2 antibody can be used for detection of DEDD2 by Western blot at 0.5 to 2 μ,g/mL.

Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: DEDD2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: DEDD2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu DEDD2

Target: DEDD2 (Death Effector Domain Containing 2 (DEDD2))

Andere Bezeichnung: DEDD2

Hintergrund: DEDD2 Antibody: Apoptotic signals are often triggered by cell surface death receptors through protein-protein interactions mediated by conserved domains such as the death effector domain. A novel death effector domain (DED)-containing protein, DEDD2, has been recently identified and its over-expression in transfected cells induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD. More recently, work has shown that DEDD2 can bind caspase-8 and -10 in addition to FLIP but not FADD. Like the related protein DEDD, DEDD2 translocates from the cytosol to the nucleus upon induction of apoptosis, and it has been suggested that DEDD2 may target caspase-8 to the nucleus and that DEDD2 thus plays a critical role in death receptor-induced apoptosis. At least two alternatively spliced transcript variants encoding distinct isoforms have been found for DEDD2.

Gen-ID: 162989

NCBI Accession: NP_579874

UniProt: Q8WXF8