AVEN Antikörper (N-Term)

Produktnummer ABIN6990367

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch AVEN in WB, ELISA, IF und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für AVEN Antikörper (N-Term) (ABIN6990367)

Target: AVEN (Apoptosis, Caspase Activation Inhibitor (AVEN))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AVEN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-AVEN Antikörper

Bindungsspezifität: N-Term

Aufreinigung: Aven Antibody is affinity chromatography purified via peptide column.

Immunogen: Aven antibody was raised against a 18 amino acid synthetic peptide from near the amino terminus of human Aven. The immunogen is located within the first 50 amino acids of Aven.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Aven antibody can be used for detection of Aven by Western blot at 1 μ,g/mL. Despite its predicted molecular weight, Aven often migrates at 55 kDa in SDS-PAGE. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Aven Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: Aven antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu AVEN

Target: AVEN (Apoptosis, Caspase Activation Inhibitor (AVEN))

Andere Bezeichnung: Aven

Hintergrund: Aven Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Aven is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that Aven functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that Aven impedes Apaf-1-mediated caspase activation. Higher levels of Aven mRNA are seen in patients with acute leukemia than in control patients, suggesting that Aven may be useful as a prognostic indicator in leukemia patients.

Gen-ID: 57099

NCBI Accession: NP_065104

UniProt: Q9NQS1