TNP1 Antikörper (N-Term)

Produktnummer ABIN6990354

Der Kaninchen Polyklonal anti-TNP1 Antikörper (ABIN6990354) detektiert spezifisch TNP1 in WB, ELISA, IF und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für TNP1 Antikörper (N-Term) (ABIN6990354)

Target: TNP1 (Transition Protein 1 (During Histone To Protamine Replacement) (TNP1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TNP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-TNP1 Antikörper

Bindungsspezifität: N-Term

Aufreinigung: TP1 Antibody is affinity chromatography purified via peptide column.

Immunogen: TP1 antibody was raised against a 20 amino acid synthetic peptide from near the amino terminus of human TP1. The immunogen is located within the first 50 amino acids of TP1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: TP1 antibody can be used for detection of TP1 by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: TP1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: TP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu TNP1

Target: TNP1 (Transition Protein 1 (During Histone To Protamine Replacement) (TNP1))

Andere Bezeichnung: TP1

Hintergrund: TP1 Antibody: Telomerase is an RNA-dependent DNA polymerase that uses an RNA component to add telomeric repeat sequences at the ends of chromosomes. Besides the RNA component which serves as the template that specifies the telomeric repeat, the telomerase complex contains a reverse transcriptase protein (TRT) and various accessory proteins including the telomerase-associated protein 1 (TP1). Telomerase activity is low in most somatic cells, causing the gradual shortening of telomeres which can ultimately lead to telomere fusion and cell death. High levels of telomerase activity are widely seen in cancerous cells and while recent experiments have suggested that telomerase may be a viable target in cancer therapy, expression levels of TP1 do not correlate with malignancy. At least two isoforms of TP1 are known to exist.

Molekulargewicht: Predicted: 290 kDa

Observed: 290 kDa

Gen-ID: 7011

UniProt: Q99973