FAIM Antikörper (C-Term)

Produktnummer ABIN6990345

Dieses Anti-FAIM-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von FAIM in WB und ELISA. Geeignet für Human und Maus.

Kurzübersicht für FAIM Antikörper (C-Term) (ABIN6990345)

Target: FAIM (Fas Apoptotic Inhibitory Molecule (FAIM))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FAIM Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-FAIM Antikörper

Bindungsspezifität: C-Term

Aufreinigung: FAIM Antibody is affinity chromatography purified via peptide column.

Immunogen: FAIM antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human FAIM. The immunogen is located within the last 50 amino acids of FAIM.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FAIM antibody can be used for detection of FAIM by Western blot at 5 - 10 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: FAIM Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: FAIM antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu FAIM

Target: FAIM (Fas Apoptotic Inhibitory Molecule (FAIM))

Andere Bezeichnung: FAIM

Hintergrund: FAIM Antibody: The susceptibility of primary splenic B cells to Fas-mediated apoptosis is regulated in a receptor-specific fashion. Terminal effectors of B cell Fas-resistance include the known anti-apoptotic proteins Bcl-xL, FLIP, and a recently identified protein termed FAIM. This molecule is broadly expressed in various tissues and exists in at least three isoforms. It is thought that resistance to Fas killing via increased expression of FAIM protects foreign antigen-specific B cells during interactions with FasL-bearing T cells whereas autoreactive B cells are deleted via Fas-dependent cytotoxicity. More recent results have indicated that FAIM interacts with both Trk and p75 neurotrophin receptor and may play a role in promoting neurite outgrowth in different neuronal systems by a mechanism involving the activation of NF-κ,B and the Ras-ERK pathway.

Gen-ID: 55179

NCBI Accession: NP_060617

UniProt: Q9NVQ4