BACE2 Antikörper (N-Term)

Produktnummer ABIN6990328

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch BACE2 in WB, ELISA und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human, Ratte und Maus.

Kurzübersicht für BACE2 Antikörper (N-Term) (ABIN6990328)

Target: BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BACE2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-BACE2 Antikörper

Bindungsspezifität: AA 30-80, N-Term

Aufreinigung: BACE2 Antibody is affinity chromatography purified via peptide column.

Immunogen: BACE2 antibody was raised against a 16 amino acid peptide near the amino terminus of human BACE2. The immunogen is located within amino acids 30 - 80 of BACE2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: BACE2 can be used for detection of BACE2 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 10 μ,g/mL.

Antibody validated: Western Blot in human and mouse samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: BACE2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: BACE2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu BACE2

Target: BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))

Andere Bezeichnung: BACE2

Hintergrund: BACE2 Antibody: Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1. BACE2 also cleaves APP at beta-site and at a different site within Abeta. BACE2 locates on chromosome 21q22.3, the so-called 'Down critical region', suggesting that BACE2 and Abeta may also contribute to the pathogenesis of Down syndrome.

Molekulargewicht: Predicted: 57 kDa

Observed: 66 kDa

Gen-ID: 25825

UniProt: Q9Y5Z0