BCAP31 Antikörper (C-Term)

Produktnummer ABIN6990280

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch BCAP31 in WB, ELISA und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für BCAP31 Antikörper (C-Term) (ABIN6990280)

Target: BCAP31 (B-Cell Receptor-Associated Protein 31 (BCAP31))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BCAP31 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-BCAP31 Antikörper

Bindungsspezifität: C-Term

Aufreinigung: BAP31 Antibody is affinity chromatography purified via peptide column.

Immunogen: Anti-BAP31 antibody was raised against a peptide corresponding to 17 amino acids near the carboxy terminus of human BAP31. The immunogen is located within the last 50 amino acids of BAP31.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 0.5-2 μ,g/mL, IHC: 2 μ,g/mL.

Antibody validated: Western Blot in human, mouse and rat samples, Immunohistochemistry in rat samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: BAP31 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: BAP31 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu BCAP31

Target: BCAP31 (B-Cell Receptor-Associated Protein 31 (BCAP31))

Andere Bezeichnung: BAP31

Hintergrund: BAP31 Antibody: Bap31 and the related protein Bap29 are endoplasmic reticulum (ER) and ER-vesicle membrane proteins and members of the B-cell receptor-associated protein family. These two proteins are highly homologous and can form homo- and heterodimers. Bap31 is thought to be involved in the intracellular trafficking of several molecules such as MHC Class I molecules and CD11b/CD18. It may also play a role in the initiation of ER stress-induced apoptosis through its association with caspase-8 via a death effector domain in its cytoplasmic tail, possibly through the promotion of membrane fragmentation and the release of cytochrome c from mitochondria. Bap31 itself contains two caspase cleavage sites and is cleaved during apoptosis. The p20 fragment of Bap31, when expressed ectopicially, is also a potent inducer cell death.

Molekulargewicht: Predicted: 28kD

Observed: 28kD kDa

Gen-ID: 10134

NCBI Accession: NP_005736

UniProt: P51572

Pathways: Positive Regulation of Endopeptidase Activity