GFRA1 Antikörper (AA 360-410)

Produktnummer ABIN6990250

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch GFRA1 in WB, ELISA, IF und IHC (p). Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für GFRA1 Antikörper (AA 360-410) (ABIN6990250)

Target: GFRA1 (GDNF Family Receptor alpha 1 (GFRA1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GFRA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-GFRA1 Antikörper

Bindungsspezifität: AA 360-410

Spezifität: GFR alpha 1 antibody is predicted to not cross-react with other members of the GFR alpha family of proteins.

Aufreinigung: GFR alpha 1 Antibody is Antibody is DEAE purified.

Immunogen: GFR alpha 1 antibody was raised against a 14 amino acid peptide near the center of human GFR alpha 1. The immunogen is located within amino acids 360 - 410 of GFR alpha 1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: GFR alpha 1 antibody can be used for detection of GFR alpha 1 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 1 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: GFR alpha 1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: GFR alpha 1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu GFRA1

Target: GFRA1 (GDNF Family Receptor alpha 1 (GFRA1))

Andere Bezeichnung: GFR alpha 1

Hintergrund: GFR alpha 1 Antibody: Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRalpha, which is a cell surface receptor for GDNF. The cDNAs encoding GDNFRalpha from human, rat, chicken and mouse have been cloned recently. GDNFRalpha was also termed Ret ligand 1 (RETL1) or TGF-beta-related neurotrophic factor receptor 1 (TrnR1) and nominated as GFRα,-1 recently. GFRα,-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFRα, and the Ret PTK form a complex to transduce GDNF signal and to mediate GDNF function.

Molekulargewicht: 51 kDa

Gen-ID: 2674

UniProt: P56159