CCR3 Antikörper (C-Term)

Produktnummer ABIN6990236

Der Kaninchen Polyklonal Anti-CCR3-Antikörper wurde für WB, ELISA, IHC (p) und IF validiert. Er ist geeignet, CCR3 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für CCR3 Antikörper (C-Term) (ABIN6990236)

Target: CCR3 (Chemokine (C-C Motif) Receptor 3 (CCR3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CCR3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Produktdetails anti-CCR3 Antikörper

Bindungsspezifität: C-Term

Spezifität: At least three isoforms of CCR3 are known to exist, this antibody will detect all three isoforms.

Aufreinigung: CCR3 Antibody is affinity chromatography purified via peptide column.

Immunogen: CCR3 antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human CCR3. The immunogen is located within the last 50 amino acids of CCR3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: CCR3 antibody can be used for the detection of CCR3 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: CCR3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: CCR3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu CCR3

Target: CCR3 (Chemokine (C-C Motif) Receptor 3 (CCR3))

Andere Bezeichnung: CCR3

Hintergrund: CCR3 Antibody: Human immunodeficiency virus (HIV) and related virus require coreceptors to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b, CCR8, GPR15, STRL33, and CX3CR1 in the chemokine receptor family were recently identified as HIV coreceptors. CCR5, CXCR4 and CCR3 are the principal receptors for HIV fusion and entry of target cells. CCR3 facilitates infection by a subset of virus. CCR3 and CCR5 promote efficient infection of microglia, the major target cells in the CNS. High levels of CCR3 and CXCR4 expression were found on the neurons from both the central and peripheral nervous systems. The CCR3 ligand, eotaxin, and an anti-CCR3 antibody inhibited HIV infection of microglia. These results indicate CCR3 plays an important role in HIV infection of CNS.

Molekulargewicht: Predicted: 39, 41 kDa

Observed: 52 kDa

Gen-ID: 1232

NCBI Accession: NP_847899

UniProt: P51677